PHARMACOLOGICAL PROPERTIES The active ingredients of the drug "THIAM-OXY" are anti-biotics tiamulin and oxytetracycline, showing a synergistic effect when acting on pathogens of infectious diseases. The mechanism of action of this combination is that both antibiotic molecules block the same metabolic pathways, that is, the synthesis of bacterial protein by acting at the level of the 50S ribosomal subunit for tiamulin and the 30S and 50S subunits for oxytetracycline. Thiam-oxy has a broad spectrum of antimicrobial action. The drug is active against Brachyspira hyodysenteriae, Brachyspira pilosicoli, Mycoplasma spp., E. coli, Salmonella spp., Lawsonia intracellularis, Clostridium perfringens, Campylobacter coli, Streptococcus spp., Staphylococcus Borchino spp., Pasilteuretella spp., Pasilteuretella spp. , Erysipelothrix rushiopatiae, Haemophilus pleuropneumoniae, Chlamydia spp .. Listeria monocito-genes, Klebsiella pneumoniae and some others. After psroral administration of the drug, active substances are absorbed from the gastrointestinal tract and reach a maximum concentration in the blood serum after 2-4 hours, and then are distributed in the tissues of the body. Thiamulin is largely retained in the tissues of the lungs and colon, the highest levels of tetracyclines are found in the kidneys, liver and bones. The oral bioavailability of tiamulin reaches 90%. Oxytetracycline is absorbed mainly in the stomach and small intestine (up to 60%). In the gastrointestinal tract, tetracyclines can bind with bivalent metals (Ca, Fe, Cu, Co, Zn, Mn), antacids and dairy products, thus forming chelate compounds that are not absorbed and excreted in feces. The bioavailability of tetracyclines increases when given to animals on an empty stomach. Most of tiamulin (60-65%) through bile is excreted from the body with feces, 30-35% - with urine. Oxytetracycline is excreted through the kidneys in the urine unchanged or in the form of metabolites, about 10% - with feces. PROCEDURE FOR USE OF THE PREPARATION Thiam-oxy is used for medicinal purposes in pigs for dysentery , mycoplasma bronchopneumonia, infectious atrophic rhinitis, edema disease, colibacteriosis. salmonellosis, actinobacillary pleuropneumonia, hemophilia and other diseases caused by microorganisms sensitive to tiamulin and oxytetracycline. The drug is administered to pigs as part of a medicinal feed at a dose of 300-500 g per 100 kg of feed for 5 days (which corresponds to a dose: 6.0 mg of tiamulin and 45.0 mg of oxytetracycline per 1.0 kg of animal body weight in day). The medicinal food with the preparation is placed in feeders cleaned of unused food residues as the only source of nutrition. After carrying out the recommended period of treatment, the feeders are filled with the usual compound feed. It is not recommended to use the drug in conjunction with ionophore antibiotics: monensin, narasin, salinomycin and lasalocide, as well as simultaneously with milk and dairy products, calcium, magnesium, zinc, iron preparations , copper, cobalt. Do not administer to animals with hypersensitivity to tetracyclines, thiamulin and renal failure. 3.4 During the treatment period in some pigs, side effects are possible in the form of skin erythema and superinfection caused by microorganisms resistant to tiamulin. 3.5 Slaughter of animals for meat is allowed 30 days after the end of the preparation. In case of forced slaughter of animals earlier than the specified time, meat and internal organs are used as feed for carnivores. PERSONAL PREVENTION MEASURES All work with the drug is recommended to be carried out in overalls with the use of personal protective equipment observing safety regulations. Do not smoke, drink or eat while working. It is forbidden to work with the drug for persons with hypersensitivity to tiamulin and tetracyclines. PROCEDURE FOR SUBMITTING CLAIMS In case of complications after using the drug, its use is stopped, the consumer applies to the state veterinary institution on the territory of which he is located. Veterinary specialists of this institution study compliance with all rules for using the drug in accordance with the instructions. When a negative effect of the drug on the animal's body is revealed, veterinary specialists take samples in the required amount for laboratory tests, draw up a sampling report and send it to the State Institution "Belarusian State Veterinary Center" for confirmation of compliance with regulatory documents.