InoxelFor the treatment of diseases of bacterial etiology in cattle and pigs, prevention of bacterial infections in chickens < h3>General informationTrade name of the medicinal product: Inoxel.International nonproprietary name: ceftiofur.Dosage form: powder for the preparation of a solution for injection. Inoxel as an active substance in 1 bottle contains ceftiofur sodium-1.06 g (equivalent to 1 g of ceftiofur) or 4.2 g (equivalent to 4 g of ceftiofur).In appearance, the drug is an amorphous powder of white or light beige color.Inoxel is produced in the form of a sterile powder, packaged in 1.06 g or 4.2 g in glass vials with a capacity of 20 ml or 80 ml, respectively. The powder bottles are packed in individual cardboard boxes.Store Inoxel in the closed packaging of the manufacturer, separately from food and feed, in a dry place, protected from direct sunlight, at a temperature of 5 0C to 20 0C. The shelf life of the drug under the conditions of storage in a closed package is 2 years from the date of production, after opening the bottle – 28 days < br>It is forbidden to use Inoxel after the expiration date. Inoxel should be stored out of the reach of children.Unused medicinal product is disposed of in accordance with the requirements of the legislation. Pharmacological propertiesInoxel belongs to the antibacterial drugs of the cephalosporin group.Ceftiofur sodium, which is part of the drug, has a wide spectrum of antibacterial action on Gram-negative and gram-positive bacteria, including strains that produce beta-lactamase, and some anaerobic bacteria, including: Escherichia coli, Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Haemophilus somnus, Actinobacillus pleuropneumoniae, Haemophilus parasuis, Salmonella cholerasuis, Salmonells typhimurium, Streptococcus suis, Streptococcus zooepidemicus, Streptococcus equi, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus bovis, Pasteurella spp., Staphilococcus spp., Actynomyces pyogenes, Klebsiela, Citrobacter, Enterobacter, Bacillus spp., Proteus spp., Fusobacterium necrophorum and Porphiromonas assacharolytica (Bacteroides melaninogenicus). The mechanism of the bactericidal action of the antibiotic is to inhibit the synthesis of the cell wall of the bacterium. After parenteral administration, ceftiofur enters the systemic bloodstream, is rapidly metabolized, reversibly binds to plasma proteins, and is concentrated at the sites of inflammation.The maximum concentration of the antibiotic in the blood plasma after intramuscular administration of the drug is reached in 0.5-2 hours and remains at the therapeutic level for up to 24 hours. The antibiotic is excreted from the body mainly in the urine and partially with feces, the half-life, depending on the type, age of the animal and the method of administration, is 10-19 hours.< br> Inoxel by the degree of exposure to the animal body belongs to the moderately dangerous substances (hazard class 3 according to GOST 12.1.007). Application procedureInoxel is prescribed for the treatment of bacterial respiratory infections in cattle caused by Pasteurella haemolytica, Pasteurella multocida, Haemophillus somnus, Actinobacillus pleuropneumoniae, and pigs caused by Pasteurella haemolytica, Pasteurella multocida, Haemophillus somnus, Actinobacillus pleuropneumoniae, Salmonella cholerasuis, Streptococcus suis; for the treatment of necrobacteriosis associated with Fusobacterium necrophorum and Porphiromonas assacharolytica (Bacteroides melaninogenicus in cattle, and for the prevention of early death of one-day-old chickens caused by Escherichia coli and Staphylococcus aureus. Contraindication to the use of Inoxel is an increased individual sensitivity of the animal to antibiotics of the cephalosporin group.Inoksel used for animals parenterally in a sterile solution, making the vial 1.06 g sterile powder make 20 ml of solvent (water for injection, saline diluent for vaccines Marek (if the drug is used to treat birds)), in a bottle from 4.02 g of sterile powder 80 ml of solvent. Dissolution Inoksela should be carried out as quickly as possible, water for injection (water for injection, saline diluent for vaccines Marek (if the drug is used to treat birds)), type in a sterile syringe with a large amount of needle with a large diameter and contribute to the vial with powder, then shake the vial immediately until the powder is completely dissolved. The resulting therapeutic solution contains 50 mg of ceftiofur /ml. The term of use of the therapeutic solution is: when stored in a dark place at a temperature of 5°C to 20°C – 12 hours, when stored in the refrigerator at a temperature of 2°C to 8°C-7 days, when stored in frozen form at a temperature of minus 4 ° C to minus 18°C-8 weeks.The therapeutic solution is administered to the animal once a day in the following doses: - to cattle-intramuscularly 1 ml per 50 kg of weight (1 mg of ceftiofur per 1 kg of animal weight). The course of treatment for respiratory diseases caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni – 3-5 days; for acute interdigital necrobacillosis (panaritium, hoof rot) caused by Fusobacterium necrophorum and Bacteroides melaninogenicus – 3 days; - pigs – intramuscularly 1 ml per 16 kg of weight (3 mg ceftiofura per 1 kg of animal weight). The course of treatment for respiratory diseases caused by Pasteurella multocida, Actinobacillus pleuropneumonia and Streptococcus suis is 3-5 days; - one-day-old chickens-subcutaneously in the neck at a dose of 0.2 ml. Before administration to chickens, the standard solution (50 mg of ceftiofur/ml) is diluted with water for injection in accordance with the table, so that 0.2 ml of the administered solution contains 0.08 – 0.2 mg of ceftiofur (3 column of the table).TableDose of ceftiofur/chicken Volume of standard Inoxel solution (50 mg / ml) Volume of added solvent1 2 30.08 mg 1 ml 124 ml < br>0.10 mg 1 ml 99 ml < br>0.12 mg 1 ml 82 ml0.14 mg 1 ml 70 ml0.16 mg 1 ml 61 ml0.18 mg 1 ml 54 ml0.20 mg 1 ml 49 mlWith an overdose of the drug, the animal may experience a decrease in appetite, inflammatory reaction at the injection site.Features of the action at the first administration of the drug and at its cancellation were not revealed.Skipping the next dose of the drug should be avoided, as this can lead to a decrease in therapeutic effectiveness. In case of missing one dose, it is necessary to introduce it as soon as possible, then the interval between injections of the drug does not change.Side effects and complications when using Inoxel in accordance with this instruction, as a rule, are not observed. In some animals, a local reaction may occur at the injection site in the form of edema, which resolves spontaneously within a few days. With increased individual sensitivity to the drug and the manifestation of allergic reactions, the use of the drug is discontinued and the animal is prescribed antihistamines and symptomatic therapy.Inoxel should not be prescribed simultaneously with drugs of bacteriostatic action, due to a decrease in its bactericidal activity, as well as mixed in one syringe with other drugs.Slaughter of cattle for meat is allowed no earlier than 24 hours, pigs-no earlier than 48 hours after the last application of Inoxel. The meat of animals that were forcibly killed before the expiration of these terms can be used as food for fur-bearing animals. Milk of dairy cows during and after the use of Inoxel is allowed to be used for food purposes without restrictions. Personal prevention measuresWhen working with Inoxel, you should follow the general rules of personal hygiene and safety, provided for when working with medicines. At the end of the work, wash your hands with warm water and soap.In case of accidental contact of the drug with the skin or mucous membranes of the eye, they should be washed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with Inoxel. In case of allergic reactions or accidental ingestion of the drug in the human body, you should immediately contact a medical institution (you should have the instructions for using the drug or the label). Empty vials from under the drug may not be used for household purposes, they are subject to disposal with household waste.Manufacturer:< / h3> < p>VETANCO S. A.; Chile 33 B 1603 CMA Vicinte Lopez, Buenos Aires, Argentina.

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